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Updated: Jan 16, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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从 (S) - 利甲中合成具有 κ 受体亲和性的纯 morphan 衍生物的基拉尔池合成

Lea Flämig1, Thomas Schidelko1, Luca Blicker1

  • 1Universität Münster, Institut für Pharmazeutische und Medizinische Chemie, Corrensstraße 48, D-48149, Münster, Germany.

European journal of medicinal chemistry
|October 4, 2025
PubMed
概括

新的吗啡衍生物被合成为潜在的卡帕 (κ) 受体激动剂. 化合物29显示出更好的选择性和抗炎作用,提供了一个有前途的治疗途径.

关键词:
奇拉尔池合成 奇拉尔池合成计算研究是计算研究.库尔蒂乌斯的重新安排乙烯基二胺是一种连接物-脂性效率 LLE LLE莫尔芬 (Morphan) 是一个孤儿.里亚甲是一种危险甲.选择性的选择性κ-阿片类受体的亲缘关系

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