短期暴露于颗粒物和表面温度与意大利的精神分裂症严重程度有关
Paola Monti1, Simona Iodice1, Enrico Capuzzi2
1EPIGET Lab, Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan, Via Sforza, 35, 20122 Milan, Italy.
暴露于空气污染,特别是PM10,与温暖的月份精神分裂症严重程度的增加有关. 较高的表面温度 (AT) 在寒冷的季节也会使症状恶化,这表明环境因素会影响心理健康.
科学领域:
- 环境健康 环境健康
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 精神分裂症是一种复杂的疾病,具有多因素的原因.
- 环境因素越来越多地被认为在精神分裂症发病和进展中的作用.
研究的目的:
- 调查空气污染物 (PM2.5,PM10,黑碳) 和表面温度 (AT) 与精神分裂症严重程度之间的关联.
- 分析这些关联在不同的季节和时间滞后.
主要方法:
- 在意大利米兰对278名精神分裂症患者 (890人入院) 进行了回顾性横截面研究 (2002-2021年).
- 使用正负综合征量表 (PANSS) 评估的精神分裂症严重程度.
- 使用区域空气质量监测和气象数据估计的空气污染物和AT暴露;用分布式滞后非线性模型分析.
主要成果:
- 累计短期暴露于颗粒污染物 (PM10) 与春夏期间的PANSS分数增加有关.
- 秋冬期间明显体温 (AT) 升高与精神分裂症症状恶化相关 (滞后0和-1).
结论:
- 空气污染和表面温度是可改变的风险因素,影响精神分裂症的严重程度,季节性变化.
- 研究结果强调需要有针对性的预防策略,以解决精神分裂症管理中的环境暴露问题.
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