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暴露于兰巴达-甲胺增强了ApoE^-/-小鼠中动脉样硬化的发展

Lei Yu¹, Haiyan Chen², Lingcheng Li³

¹Central Lab, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Ecotoxicology and environmental safety

|October 4, 2025

概括

暴露于兰巴-甲 (LCT) 会通过增加斑块形成和改变脂质代谢,使小鼠的动脉样硬化恶化. 便代谢变化被确定为这种杀虫剂诱导的疾病的潜在贡献因素.

科学领域:

环境毒理学环境毒理学
代谢学代谢学代谢学
心血管研究的心血管研究.

背景情况:

兰巴达-甲 (LCT) 是一种与代谢障碍相关的甲类杀虫剂.
动脉样硬化 (AS) 对LCT的具体影响需要进一步研究.

研究的目的:

为了确定LCT对阿波利波蛋白E缺陷 (ApoE-/-) 的小鼠AS发育的影响.
探索LCT诱导的AS中代谢变化的作用.

主要方法:

在使用高脂肪饮食 (HFD) 的ApoE-/-小鼠中诱导了动脉样硬化.
小鼠被暴露于单独的LCT (1mg/kg/天) 或HFD,持续了15天.
通过LC-MS分析大动脉组织,血清和便样本,以检测动脉样硬化病变,脂质概况和代谢物变化.
对基因表达数据集 (GSE122165,GSE124081) 进行了生物信息学分析.

主要成果:

与对照组相比,LCT暴露显著增加了大动脉斑块形成和血清甘油三水平.
代谢分析显示,在暴露于LCT的小鼠中,有159种显著改变的代谢物,涉及脂质和胆固醇代谢途径.
特定的三糖类物种 (TG 16:0/16:1/16:1) 被确定为潜在的调解者.
基因表达分析表明,LCT通过Cyp3a13和Cyp2b10等基因影响新陈代谢过程.

结论:

兰巴达-甲 (LCT) 在ApoE-/-小鼠中加剧动脉样硬化.
便代谢变化在LCT诱导的动脉样硬化病变恶化中起作用.

关键词:

动脉样硬化是一种动脉样硬化.兰巴达-甲氨酸三素脂质新陈代谢脂质新陈代谢甘油三化物是一种三糖化物.

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