伪虫 (Pseudomonas guariconensis) 死亡性软组织感染,丹麦
Sofus Rønne Soltau1, Nina Elisabeth Pontoppidan Monrad2, Allan Evald Væver Nielsen3
1Hvidovre Hospital, Department of Clinical Microbiology, Denmark.
Diagnostic microbiology and infectious disease
|October 4, 2025
概括
本案例报告详细介绍了由Pseudomonas guariconensis引起的死软组织感染 (NSTI) 的成功治疗方法. 由于美罗胺耐药性,替代性抗生素对于患者的康复至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 手术感染 手术感染
背景情况:
- 死软组织感染 (NSTI) 是一种严重的疾病,需要及时干预.
- 包括P. guariconensis在内的Pseudomonas物种可以引起攻击性的感染.
- 之前曾报道过P. guariconensis的美罗胺耐药性,这给治疗带来了挑战.
研究的目的:
- 报告第一个成功治疗Pseudomonas guariconensis引起的NSTI.
- 突出挑战和有效的策略,以管理耐美罗胺P. guariconensis感染.
主要方法:
- 一名72岁的男性患者被诊断出患有NSTI.
- 最初的实证治疗是使用美罗和克林达米辛,然后进行手术除菌.
- 培养物鉴定Pseudomonas guariconensis和随后的抗生素敏感性测试.
主要成果:
- 鉴定出 Pseudomonas guariconensis 是该病的致病原体.
- 该分离物对美罗和其他几种抗生素表现出耐药性.
- 通过切换到 cefiderocol,然后是 ceftazidim 和 ciprofloxacin,获得了成功的治疗.
结论:
- 传染病Pseudomonas guariconensis,特别是NSTI,需要谨慎管理,因为高率的美罗胺耐药性.
- 快速的抗生素敏感性测试和治疗调整对于成功的结果至关重要.
- 克林达米辛对 Pseudomonas 种类无效.
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