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用于慢性伤口修复的多功能自愈水凝:设计,机制和应用

Xuyang Ning¹, Hong Lu², Huiying Zeng¹

¹Department of Burns & Plastic Surgery, Guangzhou Red Cross Hospital, Faculty of Medical Science, Jinan University, Guangzhou 510006, China; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 510006, China; College of Pharmacy, Jinan University, Guangzhou 510006, China.

Journal of controlled release : official journal of the Controlled Release Society

|October 4, 2025

概括

多功能自愈水凝通过自主修复并提供抗微生物,抗炎和再生性质,为慢性伤口提供了有前途的解决方案. 这些先进的生物材料显著提高了伤口愈合结果和神经血管再生.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
伤口愈合治愈伤口愈合

背景情况:

慢性伤口是由于诸如高血糖,感染,缺血和炎症等复杂因素造成的,这些因素会影响愈合.
这些因素破坏细胞平衡,血管生成和细胞外基质重塑,阻碍伤口修复.

研究的目的:

审查慢性伤口管理的多功能自我愈合水凝的最新进展.
分析这些水凝的制备,性能和应用,重点关注自我愈合机制和神经血管再生.

主要方法:

关于慢性伤口愈合和自我愈合水凝的当前文献的综述.
对水凝制备机制,功能性质 (抗菌,抗炎等) 的分析. ) 和机械特性.
在促进血管生成和神经修复方面对水凝应用进行批判性评估.

主要成果:

多功能自愈水凝具有生物相容性,自主修复性和多种治疗特性.
这些水凝在改善慢性伤口愈合方面具有显著的潜力,包括增强神经血管再生.
该研究提供了对自我愈合机制和与临床转化相关的功能属性的全面分析.

结论:

多功能自我愈合的水凝代表了治疗慢性伤口的变革性方法.
对智能水凝和新生物材料的进一步研究对于创新的伤口护理解决方案至关重要.
这些先进的水凝在慢性伤口管理中具有未来临床应用的巨大潜力.

关键词:

慢性伤口是慢性伤口.多功能生物材料多功能生物材料自愈的水凝可以自我治愈.智能水凝是一种智能水凝.伤口愈合伤口愈合

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