相关实验视频

Updated: Jan 16, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

一个双 PROTAC 纳米载体放大了癌症免疫治疗的 DNA 损伤和 STING 激活

Hangyu Zhou¹, Xueping Luo¹, Chuyu Huang²

¹Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, the NMPA and State Key Laboratory of Respiratory Disease, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 510700, PR China.

Journal of controlled release : official journal of the Controlled Release Society

|October 4, 2025

概括

这项研究开发了一种新型的双降解纳米载体 (Sd@Lip) 来放大DNA损伤并激活STING通路. 这种方法在乳腺癌模型中显著提高了免疫检查点阻塞疗法的有效性.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
纳米技术纳米技术

背景情况:

细胞质DNA积累激活了STING通路,增强了抗瘤免疫力.
免疫检查点阻塞 (ICB) 疗法显示出前景,但需要改进疗效的策略.
准DNA损伤修复通路可以诱导免疫细胞死亡.

研究的目的:

开发一种对刺激有反应的纳米载体 (Sd@Lip),用于双重向蛋白质降解.
通过放大DNA损伤和STING通路激活来强化ICB疗法.
为了评估Sd@Lip与ICB在乳腺癌治疗中的疗效.

主要方法:

在对酸敏感的脂质体纳米载体 (Sd@Lip) 中,共同封装BRD4和PARP1降解剂 (dBET1和SK-575).
通过抑制非同类末端连接 (NHEJ) 和同类重组 (HR) 修复通路来评估Sd@Lip诱导的DNA损伤.
评估瘤微环境中的STING通路激活,细胞因子释放和免疫细胞透.
在体内研究评估了Sd@Lip与ICB结合治疗原发性和转移性乳腺瘤的疗效.

主要成果:

Sd@Lip有效地释放了双重降解剂,增强了DNA损伤和细胞质DNA积累.
扩大的DNA损伤导致了强大的STING通路激活,增加了促炎细胞因子的释放,并增强了免疫细胞透 (NK细胞,CTLs).
结合Sd@Lip和ICB显著抑制了原发性和转移性乳腺瘤的生长.

结论:

通过Sd@Lip对PARP1和BRD4的协同降解会诱导免疫刺激性DNA损伤.
Sd@Lip通过创建免疫性瘤微环境来增强ICB疗法.
这种双重降解策略为改善乳腺癌免疫治疗结果提供了一个有希望的方法.

关键词:

造成的DNA损伤是DNA损伤.药物输送是药物输送的过程.免疫治疗是一种免疫疗法.这就是PROTAC.激活STING的激活方式

更多相关视频

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles

Published on: May 14, 2021

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Mutagenicity and Carcinogenicity

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...