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阿尔茨海默病中的TDP-43:病理生理学和治疗策略

Xinyu Zhou1, Xianmei Lin2, Yuqi He3

  • 1Department of Geriatrics, Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, Guizhou, China; Department of Neurology, Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, Guizhou, China.

Pharmacological research
|October 4, 2025
PubMed
概括

交换性反应DNA结合蛋白43 (TDP-43) 在阿尔茨海默病 (AD) 病理学中发挥着关键作用,通过与粉样β和tau相互作用. 准TDP-43为AD治疗提供了有前途的治疗策略.

关键词:
阿尔茨海默氏症的疾病是阿尔茨海默氏症.线粒体功能障碍 线粒体功能障碍塔乌·塔乌 (Tau Tau) 是一个交换性反应DNA结合蛋白 43kDaβ-氨基化物是什么?

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