成年人体质指数和支气管扩展剂反应:分析了4个南美国家的2项基于人口的研究
Anderson N Soriano-Moreno1,2, Andres G Lescano1, Robert H Gilman3
1The School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru.
Chronic obstructive pulmonary diseases (Miami, Fla.)
|October 4, 2025
概括
较高的体重指数 (BMI) 与增加的FVC特异性支气管扩展剂响应 (BDR) 有关. 较低的BMI与喘和慢性支气管炎患者的FEV1特异性BDR有关.
科学领域:
- 肺部病理学 肺部病理学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 南美洲面临着日益严重的慢性呼吸道疾病和与体重相关的问题.
- 流行病学转型需要了解肥胖和呼吸系统健康之间的联系.
研究的目的:
- 调查南美成年人体质指数 (BMI) 和支气管扩展剂响应 (BDR) 之间的关联.
- 根据1秒内强制呼气量 (FEV1) 和强制生命能力 (FVC) 响应,区分BDR.
主要方法:
- 来自秘鲁,智利,乌拉圭和阿根廷的2项队列研究的基于人口的数据.
- 为评估BMI和BDR关系,对混因子进行了调整后勤回归分析.
- BDR定义为FEV1或FVC经支气管扩张后FEV1或FVC增加≥12%和≥200mL.
主要成果:
- 在7160名参与者中,35.5%的BMI≥30kg/m2,9.5%符合BDR标准.
- 较高的BMI (≥30 kg/m2) 与FVC特异性BDR的几率增加有关 (aOR=1.47).
- 较低的BMI (<20 kg/m2) 与喘/慢性支气管炎中的FEV1特异性BDR和慢性支气管炎中的整体BDR有关.
结论:
- BMI对特定类型的BDR有不同的影响.
- 较高的BMI与FVC特定的BDR相关,而较低的BMI在某些呼吸道疾病中与FEV1特定的BDR相关.
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