尼日利亚可能患有肺结核的儿童中细胞质菌病的患病率:一项多中心研究,比较两种诊断技术
Oluwaseun Chinaza Adereti1, Bassey E Ekeng2,3, Neil Stone4
1Department of Medical Microbiology and Parasitology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, 101006, Nigeria.
Journal of tropical pediatrics
|October 4, 2025
概括
尼日利亚儿童在疑似结核病 (TB) 的情况下,血清质症是一个重大问题. 两名儿科患者的抗原测试呈阳性,表明在资源有限的环境中需要更好的诊断.
科学领域:
- 医学真菌学 医学真菌学
- 儿科传染病 儿科传染病
- 热带医学 热带医学
背景情况:
- 关于尼日利亚儿童的组织等离子体病的数据有限,尽管它在结核病严重地区的重要性很大.
- 在尼日利亚的儿童群体中,血清症经常被误诊为结核病 (TB).
- 在低收入和中等收入国家 (LMIC) 中,这是一个关键的差异诊断.
研究的目的:
- 调查尼日利亚可能患有结核病的儿童中细胞质菌病的患病率.
- 评估抗原测定在诊断儿科组织等离子体病的实用性.
- 在资源有限的环境中解决诊断缺口.
主要方法:
- 在尼日利亚三个地区的儿科结核病诊所进行了一项描述性的横截面研究.
- 招募了100名儿童 (涉嫌结核病,确诊结核病和晚期艾滋病毒).
- 尿液样本使用MiraVista侧向流量试验 (MVD LFA) 和Clarus IMMY ELISA测试了质体抗原.
主要成果:
- 在100名参与者中,有2人使用MVD LFA.检测结果阳性,检测出Histoplasma抗原.
- 没有参与者使用ELISA方法检测出阳性.
- 阳性病例发生在未经证实结核病诊断的儿童中.
结论:
- 儿科组织等离子体病是尼日利亚儿童呈现结核病类似症状的相关诊断.
- 迫切需要在资源有限的环境中提供可访问和具有成本效益的质体病诊断工具.
- 需要进一步的研究来验证用于儿科的质体抗原测定.
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