超越PSMA:在转移性前列腺癌中,神经瘤细胞表面的点
Bilal Ashraf1, Jane McKenzie1, Andrew J Armstrong2
1Duke Cancer Institute Center for Prostate and Urologic Cancer, Duke University Department of Medicine, Division of Medical Oncology, Durham, NC, USA.
Prostate cancer and prostatic diseases
|October 4, 2025
概括
新兴的细胞表面点为转移性前列腺癌 (mPC) 提供了新的治疗选择,而转移性前列腺癌是抗标准治疗的. 这些新的目标对于开发高级成像和治疗晚期前列腺癌至关重要.
科学领域:
- 在瘤学瘤学.
- 放射化学 放射化学是指辐射化学.
- 分子成像学分子成像学
背景情况:
- 转移性前列腺癌 (mPC) 仍然是癌症死亡的重要原因.
- 对雄激素受体通路抑制剂 (ARPI) 和化疗的治疗耐药性导致mPC中的异质细胞表面抗原表达.
- 这种异质性为新型诊断成像和向治疗提供了机会.
研究的目的:
- 审查新兴的细胞表面治疗性标和转移性前列腺癌的药物.
- 确定诊断成像 (如PET) 和治疗干预的新目标.
- 在治疗耐药性的背景下讨论这些目标的相关性.
主要方法:
- 在2025年3月使用PubMed和ClinicalTrials.gov.gov进行了全面的文献搜索.
- 关键词包括"前列腺癌"",CRPC" (抵抗割的前列腺癌) 和"细胞表面点".
- 搜索的重点是识别正在进行或已完成的成像和/或治疗剂临床试验的细胞表面标.
主要成果:
- 该审查确定了13个新的细胞表面标,并提供了大量支持性文献.
- 目标根据与雄激素受体 (AR) 阳性和AR阴性mPC的相关性进行分类,包括神经内分泌前列腺癌 (NEPC).
- 收集了使用这些成像和治疗目标的正在进行和已完成的临床试验的信息.
结论:
- 多个前列腺癌细胞表面标记物正在成为有前途的治疗目标.
- 对于正在进行PSMA向治疗或不符合PSMA向治疗的患者,扩展细胞表面向策略至关重要.
- 治疗方式包括抗体-药物联合体 (ADC),细胞疗法和放射性药物疗法 (RPT).
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