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在高时空分辨率下测量三维质子FLASH剂量速率,使用一种新型的多层条带电离室 (MLSIC) 装置

Shuang Zhou¹, Arash Darafsheh¹, Zhiyan Xiao²

¹Department of Radiation Oncology, WashU Medicine, St. Louis, Missouri, USA.

Medical physics

|October 5, 2025

概括

一种新的多层条带电离室 (MLSIC) 装置可以为FLASH质子疗法进行3D剂量和剂量速率测量. 这一进展对于安全的临床实施超高剂量辐射率治疗至关重要.

科学领域:

医学物理医学物理
辐射瘤学辐射瘤学
剂量测量方法剂量测量方法

背景情况:

质子疗法为深层目标提供超高剂量速率治疗.
FLASH辐射疗法 (RT) 的临床翻译需要具有高时空分辨率的先进剂量计.

研究的目的:

为了证明FLASH笔束扫描 (PBS) 质子疗法的3D剂量和剂量速率测量的可行性.
为了验证一种新型的多层带离子化室 (MLSIC) 装置用于高分辨率剂量测量.

主要方法:

开发了一种66层的MLSIC设备,用于 (x,y) 定位有128个通道,用于深度剂量测量有32个通道.
使用高速数据读取 (6250 fps) 进行点对点测量.
使用内部算法对传统和FLASH剂量速率进行3D重建的剂量和剂量速率分布.

主要成果:

在大多数情况下,实现的离子重组率低于1%.
在重建和治疗计划软件剂量之间有很高的一致性 (例如,FLASH的99.1% 5mm/5%通过率).
成功生成了FLASH质子束的3D剂量速率分布.

结论:

在FLASH剂量速率下,MLSIC装置有效地为PBS质子束提供3D剂量和剂量速率分布.
开发的系统实现了临床FLASH RT应用所需的高时空分辨率.

关键词:

3D剂量测量 3D剂量测量一个闪光灯.电离室的电离室质子疗法是一种质子疗法.超高剂量速率的超高剂量速率

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