损伤位置和功能连接揭示了多发性硬化症中认知障碍网络
Alessandro Franceschini1, Paolo Preziosa1,2,3, Paola Valsasina1
1Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Annals of clinical and translational neurology
|October 5, 2025
概括
影响大脑连接的白质病变有助于多发性硬化症 (MS) 的认知障碍. 这些病变影响诸如海马体和丘脑等区域,但似乎不会导致疲劳或抑郁.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 多发性硬化症 (MS) 通常会导致认知障碍,疲劳和抑郁症.
- 怀疑白质病变会破坏大脑的功能连接,导致这些症状.
- 了解受WM病变影响的特定大脑网络对于MS患者护理至关重要.
研究的目的:
- 在MS患者中调查WM病变,功能性大脑连接和认知,疲劳和抑郁症状之间的关联.
- 为了确定特定的损伤网络图 (LNMs) 是否与不同的MS相关的表现相关.
主要方法:
- 596名多发性硬化患者接受了3T脑部MRI,神经和神经心理评估.
- 分析了voxel-wise损伤概率图,并与功能连接图谱联系起来.
- 基于认知功能,疲劳和抑郁症的患者子组之间进行了损伤网络图 (LNMs) 的比较.
主要成果:
- 认知障碍多发性硬化患者 (27.2%) 患有与海马体,丘脑,小脑和皮相关的广泛WM病变.
- 语言记忆缺陷与与副海马和小脑相关的病变有关.
- 语言流利性缺陷涉及与 thalamus,基底和前带带皮层相连的病变.
- 对于疲劳或抑郁,没有发现病变分布或网络连接的显著差异.
结论:
- 区域性WM病变破坏了关键大脑区域的连接,有助于MS的认知障碍.
- 这些发现表明,LNM可以帮助阐明MS认知缺陷背后的机制.
- 该研究没有发现证据表明特定的WM病变网络与MS患者的疲劳或抑郁有关.
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