基于Q标志物的白菌根体质量控制的综合战略
Jiawei Wang1, Jiajia Gong1, Jiakang Liu2
1School of Pharmaceutical Sciences, Fudan University, Shanghai 201203, China; National Key Laboratory of Lead Druggability Research, Shanghai Institute of Pharmaceutical Industry Co., Ltd., China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
Journal of pharmaceutical and biomedical analysis
|October 5, 2025
概括
这项研究确定了白条纹 (BS) 中的六种关键化合物作为质量标记物 (Q标记物). 这些Q标记物有助于区分真正的BS与其替代品,确保这种传统中医药的质量.
科学领域:
- 药理学是指药理学,即药理学是指药理学.
- 代谢学 代谢学 代谢学
- 传统中国医药 传统中国医药
背景情况:
- 布莱蒂莱树 (Bletilla striata) 是一种用于止血的传统中医药.
- 资源短缺导致使用非官方替代品,损害了质量控制.
- 开发可靠的方法来识别真正的Bletilla条纹是非常重要的.
研究的目的:
- 为了建立Bletilla条纹 (BS) 的质量控制标准.
- 为了识别和验证质量标记 (Q-标记) 的BS.
- 为了区分真正的BS与其常见的替代品.
主要方法:
- 使用非向植物代谢学,血清药理化学和活性测试的综合策略.
- 通过多技术分析识别差异成分和Q标记物.
- 使用二极管阵列检测 (UPLC-DAD) 的超高性能液态染色学同时量化Q标记物.
主要成果:
- 为了区分BS和假冒品,确定了20个不同的成分.
- 六个被吸收的成分 (白酸A,巴塔酸III,吉姆诺酸III,米利他林,桑奇古辛I,达基洛林A) 被选为Q标志物.
- 量化发现BS和大多数替代品之间的Q标记物含量存在显著差异,除了Bletilla formosana.
- 已识别的Q标志物具有静血或抗炎活性.
结论:
- 六种已识别的化合物作为可靠的Q标志物用于Bletilla条纹.
- 这些Q标记物被吸收并与BS的传统功能联系在一起.
- 开发的方法提高了Bletilla条纹及其草药制剂的质量控制.
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