从COVID-19中康复的患者的深静脉血栓症:一个长期的后续
Jennifer Reséndiz-Vazquez1, Víctor Domínguez-Reyes2, Eduardo Terán-Paredes3
1Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, Instituto Mexicano del Seguro Social, Mexico City, Mexico; Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Archives of medical research
|October 5, 2025
概括
长期患有血栓的COVID-19患者表现出功能失调的内皮细胞殖民地形成细胞 (ECFCs). 这种功能障碍的特点是减少扩散和血管生成能力,与COVID后病情 (PCC) 中的静脉血栓栓塞性疾病 (VTD) 事件有关.
科学领域:
- 心血管生物学 心血管生物学
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- 长期的COVID-19,或后COVID状态 (PCC),可能会导致持久的健康问题,包括血液凝固问题.
- 内皮形成殖民地细胞 (ECFC) 在血管健康和修复中起着至关重要的作用.
- 以前的研究表明,康复的COVID-19患者的ECFC中存在异常.
研究的目的:
- 在长期COVID-19期间,研究ECFCs在患有静脉血栓栓塞性疾病 (VTD) 或动脉血栓症 (AT) 的个体中的功能状态.
- 在COVID-19感染后有复发性未引起的VTD病史的患者中评估ECFC功能.
主要方法:
- 将35名患有COVID-19后血栓事件的患者的外周血液单核细胞 (MNC) 与10名健康对照组和10名患有COVID-19后复发性VTD的患者进行了比较.
- 在根据年龄和性别匹配的冷保存样本中评估了ECFC频率,形态,增殖和血管生成能力.
- 分析了与VTD或AT相关的潜在风险因素的实验室数据.
主要成果:
- 没有发现基于性别的显著差异或可识别的VTD/AT实验室风险因素.
- 在不同组中,ECFC频率没有差异.
- 患有VTD的患者表现出ECFC增殖能力降低,衰老增加和血管新生活性受损.
结论:
- 在COVID后病情 (PCC) 患者和ECFC功能障碍之间存在强烈的VTD事件.
- 包括减少增殖和血管生成能力在内的ECFC功能障碍与长期COVID-19幸存者的血栓事件有关.
- 这些发现强调了ECFCs在长期COVID-19血管并发症中的关键作用.
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