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高的"sarcopenia指数"降低了急性心肌梗塞患者的全因死亡率
Hui Pan1, C Yu Dong2, Z Cheng Yang3
1Department of Geriatric Medicine, Qilu Hospital of Shandong University, Key Laboratory of Cardiovascular Proteomics of Shandong Province, Qilu Hospital, Jinan, Shandong, 250012, China.
Clinical nutrition (Edinburgh, Scotland)
|October 5, 2025
概括
麻症指数 (Cr × eGFRcys) 有效预测老年急性心肌梗塞 (AMI) 患者的全因死亡率. 较高的Cr × eGFRcys表明更好的生存结果,提供了有价值的预后标记.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 腎臟醫學 腎臟醫學
背景情况:
- 麻症指数 (SI),计算为基于血清肌素和细胞素C的估计质过率 (Cr × eGFRcys) 的产物,是麻症的潜在标志物.
- 对于患有急性心肌梗塞 (AMI) 的老年患者全因死亡率的Cr × eGFRcys的预测价值仍未得到研究.
研究的目的:
- 调查Cr × eGFRcys与被诊断患有AMI的老年患者全因死亡风险之间的关联.
- 确定 Cr × eGFRcys 是否可以作为该患者群体中死亡率的独立预测指标.
主要方法:
- 一项回顾性队列研究分析了500名老年 (≥65岁) AMI患者.
- 根据ROC分析,患者被分为高和低Cr × eGFRcys组.
- 卡普兰-梅尔曲线和多变量考克斯比例危险模型评估了生存率和死亡率的独立预测因素.
主要成果:
- 高Cr × eGFRcys组的患者表现出明显更好的生存率 (逻辑等级p < 0.0001).
- 纳入Cr × eGFRcys提高了所有原因死亡率的基线风险模型的预测准确度,NRI,IDI和C指数显著提高.
结论:
- 在老年AMI患者中,Cr × eGFRcys与全因死亡率显著相关.
- 对Cr × eGFRcys的最佳切断值为53.56,表明它在这个人口群体中作为所有原因死亡率的预后标志物的实用性.
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