相关实验视频

Updated: Jan 16, 2026

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Published on: October 13, 2023

通过MAPK信号通路调节对抗结直肠癌的加兰的研究

Yingzi Wu¹, Jinhai Luo¹, Baojun Xu²

¹Food Science and Technology Program, Department of Life Sciences, Beijing Normal-Hong Kong Baptist University, Zhuhai 519087, China; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.

International immunopharmacology

|October 5, 2025

概括

加兰化合物加兰有效地抑制结肠直肠癌 (CRC) 细胞生长和转移. 它通过抑制MAPK信号通路而起作用,显示出作为潜在的CRC治疗方法的希望.

科学领域:

在瘤学瘤学.
药理学药理学是指药理学的学科.
分子生物学分子生物学

背景情况:

结肠直肠癌 (CRC) 由于转移和复发的高率,构成了全球重大健康挑战.
加兰加尔的抗癌特性是公认的,但其对抗CRC的潜在机制需要阐明.

研究的目的:

调查galangal的抗CRC作用,并确定其潜在的分子机制.
通过网络药理学探索galangal在打击CRC中的生物活性化合物,点和途径.

主要方法:

网络药理学被用来确定加兰作为加兰中的关键生物活性化合物.
在体外测试 (CCK-8,EDU,殖民地形成,伤口愈合,Transwell,西斑) 评估了galangin对CRC细胞功能的影响.
用RNA测序和西部斑分析来研究途径调制,特别是MAPK信号通路.

主要成果:

在体外,Galangin显著抑制了结直肠癌细胞的增殖和迁移,毒性最小.
甘巴林诱导了G0/G1细胞周期停止,并通过增加ROS和减少线粒体膜潜力促进了细胞灭亡.
甘拉丁通过抑制MAPK信号通路来抑制结直肠癌细胞的增殖,通过通路激活器实验证实了这一点.

结论:

甘是一种生物活性化合物,在结直肠癌细胞上表现出强大的抗增殖和抗转移作用.
对MAPK信号通路的调制是加拉发挥抗CRC作用的关键机制.
甘愿兰代表着未来结直肠癌治疗开发的有希望的候选人,值得进一步进行体内和临床研究.

关键词:

细胞灭亡 (apoptosis) 是一种死亡的过程.细胞循环的细胞周期结肠直肠癌是一种癌症.礼拜是为了祈祷.在 MAPK 信号通道中.这就是ROSOS ROS.

更多相关视频

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula

Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula

Published on: January 26, 2024

相关概念视频

MAPK Signaling Cascades

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...

Interactions Between Signaling Pathways

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...