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由于高血糖血症导致的伪高三糖血症症的心脏代谢风险
Boris Hansel1, Philippe Couvert2, Alain Carrié3
1Service d'Endocrinologie, Diabétologie et Nutrition, Hôpital Bichat-Claude Bernard, AP-HP Nord, Paris, France (Hansel, Kadouch, Jaraya); Université de Paris, Faculté de santé, UFR de médecine, Paris, France (Hansel); National Institute for Health and Medical Research (INSERM), LVTS, U1148, Paris, France (Hansel, Varret).
过高血糖,一种罕见的代谢障碍,似乎不会导致过早的动脉样硬化心血管疾病 (ASCVD). 查只推用于持续的高甘油三血症,对治疗没有反应.
科学领域:
- 代谢障碍 代谢障碍 代谢障碍
- 遗传学 是一个遗传学.
- 心血管疾病 心血管疾病
背景情况:
- 高糖血症是一种罕见的X相关的新陈代谢先天性错误.
- 极端的糖醇水平和动脉样硬化之间的关联是未知的.
- 过高糖血症的患病率仍未确定.
研究的目的:
- 在患有高血糖血症的患者中评估亚临床动脉样性心血管疾病 (ASCVD).
- 研究高血糖和动脉样硬化之间的联系.
- 确定与高糖血症相关的心血管风险.
主要方法:
- 对患有脱脂症患者 (2000-2011) 的回顾性分析.
- 在患有高甘油三血症 (>200 mg/dL) 的患者中评估血糖醇水平.
- 在已确认的高糖血症病例中进行了基因测试以检测甘油酶基因变异.
主要成果:
- 在314,268个脂质配置文件中,确定了13名生物高糖血症患者.
- 发现了X链接甘油酶基因的7种新型变异.
- 没有高葡萄糖血症患者显示出出血脉动动脉样硬化;在随访期间没有出现临床ASCVD. 三人患有亚临床动脉样硬化,同时存在心血管风险因素.
结论:
- 高血糖血与早发性ASCVD没有关联.
- 建议对持续性,耐治疗性高甘油三血症进行查,以发现高甘油三血症.
- 对被诊断为高糖血症患者来说,可能有关于心血管风险的保证,重点是监测常见风险因素.
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