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精子未成熟的生殖细胞作为微剖析的预测器丸精子提取开发一个结合的预测模型的开发

Nengqing Liu¹, Jie Chen¹, Xiaowu Fang¹

¹Reproductive Medicine Center, Boai Hospital of Zhongshan, Zhongshan, Guangdong, China.

The world journal of men's health

|October 5, 2025

概括

精液中的不成熟生殖细胞 (IGC) 预测了在接受微切割丸精子提取 (m-TESE) 的非阻塞性精子缺血症 (NOA) 患者中成功的精子提取 (SR). 包括IGC在内的模型显示,对预测m-TESE成功的准确性有所提高.

科学领域:

生殖医学生殖医学
安德罗学与人类学
不孕症研究不孕症研究

背景情况:

非阻塞性精症 (NOA) 影响男性生育能力.
微切割丸精子提取 (m-TESE) 是NOA患者精子提取 (SR) 的一个关键技术.
在NOA中预测SR的成功仍然具有挑战性.

研究的目的:

评估精液中不成熟的生殖细胞 (IGC) 与接受m-TESE的NOA患者的精子检索率 (SR) 之间的关系.
开发和验证m-TESE成功的预测模型.

主要方法:

对95名接受m-TESE (2019-2024) 的NOA患者进行了回顾性分析.
进行全面的临床,实验室和组织病理学评估.
多变量逻辑回归和五倍交叉验证以构建和评估预测模型.

主要成果:

总体的SR率为40.0%.
精液中的不成熟生殖细胞 (IGC) 是阳性SR最强的预测因素 (p<0.001,OR=13.757).
与没有IGC的模型相比,结合IGC的预测模型显示出更高的有效性和稳定性 (AUC高达0.874).

结论:

在接受m-TESE的NOA患者中,精液中IGC的存在是成功提取精子的重要预测因素.
集成IGC的模型显示了对预测m-TESE结果的增强临床实用性.
IGC分析提供了一种有价值的非侵入性工具,用于指导NOA的治疗决策.

关键词:

亚精子缺血症 (Azoospermia) 是一种胚胎细胞是发生在胚胎中的胚胎细胞.预测模型的预测模型.丸精子采集丸精子采集

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