绿色合成的银纳米颗粒的抗候群活性,用Alkanna tinctoria根制成,用于对抗多种耐药候选病原体
Khulood Saleh Alnahdi1, Fatimah Olyan Al-Otibi1,2, Abdulaziz A Al-Askar1
1Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
Scientific reports
|October 5, 2025
概括
来自Alkanna tinctoria根提取物的绿色合成银纳米颗粒显示出强大的抗真菌活性,对抗性Candida物种具有强烈的抗真菌活性. 这些纳米粒子增强了传统的抗真菌治疗方法,为具有挑战性的感染提供了有希望的解决方案.
科学领域:
- 纳米技术 纳米技术
- 菌类学 菌类学是指菌类学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 耐多药Candida感染对全球健康构成重大威胁.
- 迫切需要新的治疗策略来对抗耐药性真菌病原体.
- 银纳米粒子 (AgNPs) 已经证明具有广泛的抗微生物特性.
研究的目的:
- 使用Alkanna tinctoria根提取物 (At-AgNPs) 来合成绿色的银纳米颗粒.
- 评估At-AgNPs对各种Candida物种的抗真菌疗效,包括耐药菌株.
- 研究At-AgNPs与常规抗真菌药物结合的协同效应.
主要方法:
- 使用植物提取物进行At-AgNPs的绿色合成.
- 使用TEM,DLS,UV-Vis,EDX和XRD进行表征.
- 抗真菌活性测试包括抑制区,MIC和MFC.
- 与克洛特里马对Candida albicans的协同效应评估.
- 扫描电子显微镜 (SEM) 用于形态损伤评估.
主要成果:
- 球形At-AgNP (19.91纳米直径) 已成功合成和表征.
- At-AgNPs对包括C. auris和C. parapsilosis在内的Candida物种表现出显著的抗真菌活性.
- 最佳稳定性被证实在泽塔电位 (-23.34 mV) 和PDI (0.202) 时.
- 当At-AgNPs与克洛特里马相结合时,观察到协同作用的抗真菌作用,增强了对C. albicans的疗效.
- SEM显示,在组合治疗后,真菌细胞发生了实质性的形态损伤.
结论:
- At-AgNPs是一种稳定有效的抗真菌剂,可以对抗多药耐药的Candida.
- 与At-AgNPs的联合治疗显示了提高传统抗真菌疗效的潜力.
- 这种方法可能会导致降低药物剂量和最小化副作用在治疗耐药Candida感染.
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