电针通过Piezo1-介导的线粒体恒温减弱了炎症性肠病中的肠上皮质铁
Haolong He1,2,3, Jingying Zhou2, Sihui Cao2
1Department of Acupuncture-Moxibustion, Tuina and Rehabilitation, The Second Clinical School of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China.
Chinese medicine
|October 5, 2025
概括
电针 (EA) 通过调节Piezo1通道和抑制铁亡来缓解炎症性肠病 (IBD). 这项研究揭示了EA.
科学领域:
- 胃肠病学和肝病学
- 细胞生物学 细胞生物学
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性肠病 (IBD) 的发病包括由Piezo1通道介导的机械力量.
- 皮埃佐1在IBD中的铁亡中的作用以及电针 (EA) 的治疗潜力仍然不清楚.
研究的目的:
- 调查Piezo1介导的铁和IBD之间的联系.
- 阐明电 (EA) 在这个途径中的调节作用.
主要方法:
- 德克斯硫酸 (DSS) 诱导的IBD小鼠模型和机械应激的HIEC-6细胞被用EA或药理剂治疗.
- 评估包括病理评分,传输电子显微镜 (TEM),细胞因子测定,西部涂抹和免疫光.
- 评估了线粒体动态和铁亡标记,以了解Piezo1-ferroptosis轴和EA的影响.
主要成果:
- 在小鼠中,EA显著降低了IBD严重程度,炎症和结肠损伤.
- EA抑制了线粒体分裂 (DRP1) 和线粒体分裂 (PARK2),维持了线粒体平衡,类似于铁灭抑制剂ferrostatin-1 (Fer-1).
- 在体外,机械应激或Piezo1激活诱导铁亡,其特征是ACSL4,ROS,MDA,Fe2+,GPX4,FTH和GSH的水平发生变化. EA抑制了Piezo1的激活,并减轻了铁亡.
结论:
- 皮埃佐1介导的线粒体功能障碍是IBD肠道上皮质铁亡的关键驱动因素.
- 电针 (EA) 在治疗上准Piezo1,保持线粒体平衡并抑制铁亡.
- 通过调节Piezo1-ferroptosis轴来管理IBD,EA提出了一个有前途的治疗策略.
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