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Updated: Jan 16, 2026

Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping
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通过G4L-PROTAC通过四度复合形成,降解G-四复合结合蛋白

Rena Nohara1, Yuma Tanaya1, Mohammad Jafar Sheikhi1

  • 1Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo, 184-8588, Japan.

Angewandte Chemie (International ed. in English)
|October 6, 2025
PubMed
概括

研究人员开发了G4L-PROTACs,这些分子只在与G-quadruplexes (G4s) 结合时,才能选择性降解G-quadruplex结合蛋白 (G4BPs). 这种有针对性的方法允许精确研究细胞中的G4-G4BP相互作用.

关键词:
G-四重复合体连接体的连接体在G-四重复中.G-四重复结合蛋白质的结合蛋白.蛋白质溶解向的木乃伊 (PROTAC) 的研究.

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