模块化伊米诺素作为选择性C-H功能化的原子转移催化剂
Min Jiang1, Wei Zhang1, Pu-Sheng Wang1
1Hefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.
伊米诺酸盐作为可调节的原子转移催化剂,取代了典型的C ((sp3) -H键偏好. 光氧化催化使选择性C ((sp3) -H化成为可能,替代剂调制增强了区域选择性.
科学领域:
- 有机化学 有机化学
- 催化剂是一种催化剂.
- 摄影氧催化剂的催化作用
背景情况:
- 伊米诺酸盐是通过斯图丁格反应合成的多功能化合物.
- 原子转移 (HAT) 催化提供了一个强大的C-H功能化的方法.
- 控制C-H激活中的区域选择性仍然是有机合成的一个重大挑战.
研究的目的:
- 为了开发imininophosphoranes作为可调节的原子转移催化剂.
- 通过光氧催化,实现各种基质的选择性C(sp3) -H化.
- 通过调节氨基替代剂来增强区域选择性.
主要方法:
- 通过Staudinger反应合成伊米诺酸.
- 光氧催化剂的应用,用于C(sp3) -H化.
- 和替代物的系统变化在imininophosphorane脚手架上.
主要成果:
- 伊米诺酸催化剂成功调解了原子转移,取代了热力学C(sp3) -H键强度偏好.
- 在光氧催化下,在一系列基板上实现了选择性C ((sp3) -H化.
- 催化剂替代剂的调制允许调节性增强区域选择性,有利于硬质可访问的位置.
结论:
- 伊米诺酸盐是有效的可调节的HAT催化剂,用于C ((sp3) -H功能化.
- 光氧化催化提供了使用这些催化剂进行选择性C(sp3) -H化的平台.
- 通过替代剂调制进行催化剂设计,可以精确控制反应区域选择性.
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