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Updated: Jan 16, 2026

A Nonsequencing Approach for the Rapid Detection of RNA Editing
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A Nonsequencing Approach for the Rapid Detection of RNA Editing

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导向RNA氨酸传感器的TadA突变扫描,以尽量减少氨酸基编辑器的毒性

Cheng Zhang1, Ziliang Chen1, Jixin Cao2

  • 1Institute of Pediatrics, Children's Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200032, China.

Molecular therapy : the journal of the American Society of Gene Therapy
|October 6, 2025
PubMed
概括

腺基编辑器 (ABE) 导致RNA的目标外编辑和毒性. 研究人员开发了一种传感器,用于设计更安全的ABE,减少RNA编辑,提高治疗应用的精度.

关键词:
RNA 氨酸传感器是 RNA 氨酸传感器.在RNA的目标之外进行编辑.TadA是除氨酸酶的一种.基编辑器的编辑器

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