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Updated: Jul 13, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

从CASP13到诺贝尔奖:DeepMind的AlphaFold旅程在革命性蛋白质结构预测和超越方面

Jad Abbass1

  • 1School of Computer Science and Mathematics, Kingston University, London, UK.

Current protein & peptide science
|October 6, 2025
PubMed
概括

蛋白质结构预测被AlphaFold2显著提升,在CASP14中实现了前所未有的准确性. 这一突破使得大量的蛋白质结构数据库和进一步的蛋白质生物学研究成为可能.

关键词:
阿尔法折叠是什么意思阿尔法折叠在AlphaFold2算法中.卡斯普 (CASP) 是一种在DeepMind的基础上,DeepMind可以进行深度思考.多链蛋白质复杂结构的结构.蛋白质科学 蛋白质科学蛋白质结构预测 蛋白质结构预测

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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

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The native conformation of a protein is formed by interactions between the side chains of its constituent amino acids. When the amino acids cannot form these interactions, the protein cannot fold by itself and needs chaperones. Notably, chaperones do not relay any additional information required for the folding of polypeptides; the native conformation of a protein is determined solely by its amino acid sequence. Chaperones catalyze protein folding without being a part of the folded protein.
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