维生素D缺乏是否会导致生长疼痛? 一个案例对照研究
Isha Jain1, Abinaya K2, Nikita Agarwal2
1All India Institute of Medical Sciences, Raipur, Raipur, India.
Clinical pediatrics
|October 6, 2025
概括
这项研究发现,生长疼痛 (GPs) 和健康对照儿童之间的维生素D水平没有显著差异. 维生素D补充剂对全科医生儿童的疼痛减轻没有显著的影响.
科学领域:
- 儿科 儿科 儿科
- 营养科学 营养科学
- 肌肉骨健康 肌肉骨健康
背景情况:
- 生长疼痛 (GPs) 是4-14岁儿童常见的非炎症性肌肉骨疼痛综合征.
- 维生素D缺乏和全科医生的发展之间的潜在联系仍然是研究领域.
- 了解导致全科医生的因素对于有效的管理和家长指导至关重要.
研究的目的:
- 调查维生素D缺乏与儿童生长疼痛发生率之间的联系.
- 评估维生素D补充剂对诊断为全科医生儿童疼痛减轻的影响.
- 为了比较有和没有全科医生的儿童之间的维生素D水平和相关的生物化学标志物.
主要方法:
- 一项为期6个月的病例控制研究,涉及4至14岁的儿童,有和没有医生病史.
- 测量血清中的25-基维生素D (25-OHD),,酸盐和性酸酶水平.
- 给缺乏或不足25-OHD水平的参与者服用维生素D3补充剂.
主要成果:
- 在全科医生组 (95.6%) 和对照组 (93.3%) 均观察到25-OHD水平不足或不足的高患病率.
- 在任何一组中,血清,酸盐,性酸酶和25-OHD水平之间没有发现显著的相关性.
- 具有足够25-OHD水平的儿童经历了与接受维生素D补充剂的儿童相比的疼痛减轻.
结论:
- 该研究发现,患有生长疼痛的儿童与健康对照儿童之间的维生素D水平没有显著差异.
- 维生素D缺乏在两个群体中都非常普遍,这表明它可能不是全科医生的主要致病因素.
- 目前的研究结果不支持维生素D补充作为减少儿童生长疼痛的有针对性的干预措施.
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