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局部益生菌疗法减少化疗诱导的口腔粘膜炎:在老鼠模型中的临床前评估

Buse Kose Demirezen¹, Eren Demirpolat², Arzu Yay^3,4

¹Drug Application and Research Center (ERFARMA), Erciyes University, Kayseri, Turkey.

Fundamental & clinical pharmacology

|October 6, 2025

概括

局部益生菌,特别是乳酸菌酸,通过减少炎症和促进愈合,有效治疗口腔粘膜炎 (OM). 这项研究强调益生菌是OM管理的有前途的非全身疗法.

科学领域:

微生物学微生物学
胃肠病学胃肠病学
药理学药理学是指药理学的学科.

背景情况:

口腔粘膜炎 (OM) 是一种由化疗和放射治疗引起的痛苦疾病.
目前对OM的治疗有效性有限,缺乏再生能力.
这项研究调查了局部益生菌作为OM的潜在治疗剂.

研究的目的:

评估各种局部益生菌在口腔粘膜炎的老鼠模型中的疗效.
评估益生菌治疗对口腔粘膜的抗炎和再生作用.

主要方法:

在老鼠中使用5-甲和酸诱导口腔粘膜炎.
这些老鼠接受了局部治疗,包括Lactobacillus acidophilus,Lactobacillus reuteri,Bacillus clausii,Bacillus coagulans,Lactobacillus plantarum,sucralfate和triamcinolone等.
分析了OM的严重程度,纤维化和炎症标志物 (TNF-α,IL-10,PGE2).

主要成果:

与对照组相比,Lactobacillus acidophilus和Lactobacillus reuteri显著降低了OM的严重程度.
乳杆菌酸性通过减少纤维化和PGE2.2的抗炎和抗纤维作用.
其他益生菌显示中度有效性,而糖酸和氨酸在组织再生方面效果较差.

结论:

局部益生菌,特别是L. acidophilus,在治疗化疗诱导的OM方面显示出显著的潜力.
益生菌调节炎症,促进粘膜的愈合,提供一种新的治疗方法.
对OM局部益生菌疗法的进一步研究是有必要的.

关键词:

乳酸菌酸性菌类的乳酸菌.化疗引起的副作用口腔粘膜炎是一种口腔粘膜炎.益生菌是一种益生菌.专题局部局部局部局部

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