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Updated: Jan 16, 2026

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
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PALB2逆转突变的出现作为乳腺癌中耐尼拉巴的抵抗机制:一个案例报告

Maako Kawamura1, Hiroshi Tada2, Hidekazu Shirota3

  • 1Personalized Medicine Center, Tohoku University Hospital, Sendai, Japan.

Cancer science
|October 6, 2025
PubMed
概括

本案例研究显示,患有转移性乳腺癌和PALB2突变的患者最初对PARP抑制剂治疗有反应. 由于PALB2的逆转突变,产生了耐药性,这凸显了基因组分析的必要性.

关键词:
在CGP的测试试验中.在PALB2中,PALB2是PALB2.这是一种PARP抑制剂.乳腺癌 乳腺癌 乳腺癌逆转突变是一种逆转突变.

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