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患有胎儿生长限制的患者的血管性失衡,炎症和氧化应激:一个病例对照研究

Mehwish Iftikhar^1,2, Sumaira Sharif¹, Sawar Khan³

¹Institute of Molecular Biology and Biotechnology, The University of Lahore, Pakistan.

African journal of reproductive health

|October 6, 2025

概括

胎儿生长限制 (FGR) 涉及降低血管内皮生长因子 (VEGF) 和增加可溶性FMS类型的氨酸激酶-1 (sFlt-1),与氧化应激和炎症有关. 这些发现表明FGR的新治疗目标.

科学领域:

产科和妇科产科和妇科
周围生理学周围生理学
分子生物学分子生物学

背景情况:

胎儿生长限制 (FGR) 是一个具有重大胎儿风险的重大产科并发症.
FGR的病理生理学涉及血管新生,炎症和氧化应激途径之间的复杂相互作用.

研究的目的:

调查FGR.中的血管生成因子和炎症性细胞因子的表达.
检查这些因素与FGR怀孕中的母体氧化应激标志物之间的关联.

主要方法:

实时PCR用于分析外围血液单核细胞 (PBMC) 中的信使RNA (mRNA) 表达.
光谱测定和ELISA测量了母体血液中的氧化应激标志物.
该研究包括75例FGR病例和75例健康怀孕.

主要成果:

FGR病例显示血管内皮生长因子 (VEGF) 降低,FMS类可溶性氨酸激酶-1 (sFlt-1) 和核因子-卡帕B (NF-κB) 表达增加.
sFlt-1水平与VEGF和胎盘生长因子 (PlGF) 相反相关.
sFlt-1和NF-κB的表达与氧化应激标志物如马隆迪甲基 (MDA) 和8-基-2'-脱氧氨酸 (8-OHdG) 有积极的相关性.

结论:

FGR的特点是血管生成信号受损,氧化应激增加和炎症.
孕产妇的氧化应激和炎症与FGR中的血管原因子表达变化密切相关.
针对氧化应激和炎症可能提供改善FGR结果的治疗策略.

关键词:

胎儿生长限制胎儿生长限制葡萄糖氨酸 (Glutathione) 是一种介质素 6 介质素 6 介质素核因子卡帕 B B 的核因子胎盘生长因子胎盘生长因子瘤亡因子α因子

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