妄想与创伤后应激障碍的关联:系统性审查和元分析
Xia Yang1,2, Fang Chen1,2, Zhixia Jiang3
1School of Nursing, Zunyi Medical University, Zunyi, Guizhou, China.
Frontiers in psychiatry
|October 6, 2025
概括
这项研究发现,患有妄想症的患者患上创伤后应激障碍 (PTSD) 的风险明显更高. 早期识别和干预策略对于管理这种高风险至关重要.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 妄想是一种常见的急性脑功能障碍,涉及到可以导致妄想记忆的感知障碍.
- 这一过程可能会增加患创伤后应激障碍 (PTSD) 的风险.
- 关于妄和PTSD联系的先前研究是不一致的,需要进行系统的评估.
研究的目的:
- 为了澄清妄想症和PTSD之间的流行病学关系.
- 评估这种关联的临床意义.
- 为高风险患者提供早期识别和有针对性的干预提供证据.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 在多个数据库 (PubMed,MEDLINE,PsycINFO,Embase,Scopus,CINAHL) 进行搜索,直到2025年4月.
- 妄和PTSD的自由文本和受控词汇搜索术语组合;注册在PROSPERO (CRD420251031880).
主要成果:
- 包括11篇文章;元分析显示妄显著增加了PTSD风险 (未调整的OR=3.31,调整的OR=3.96).
- 患有妄想症的患者的PTSD症状得分显著更高 (SMD=0.50,P<0.001).
- 数据转换和对PTSD评分的分析是在使用正常分布数据的研究中进行的.
结论:
- 创伤后应激障碍 (PTSD) 和妄想之间存在显著的关联.
- 妄想是发展PTSD的一个危险因素.
- 这些发现支持了对综合护理策略的需求.
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