在患有类风湿性关节炎的患者中,由于长期的甲索特雷克萨特治疗而导致的部缺陷骨折
Julian Ramin Andresen1, Sebastian Radmer2
1Division of Trauma Surgery, Department of Orthopaedics and Trauma Surgery, Medical University of Vienna, Vienna, Austria.
Journal of surgical case reports
|October 6, 2025
概括
在患有炎症性类风湿性疾病的患者中,长期的甲索特雷克萨治疗可能会导致缺陷骨折. 早期诊断和治疗调整对于愈合和预防进一步的骨折至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 整形外科 整形外科 整形外科
- 药理学 药理学是指药理学的学科.
背景情况:
- 缺陷骨折是炎症性类风湿性疾病中已知的并发症.
- 长期的甲索特雷克萨 (MTX) 治疗是这些骨折的另一个潜在原因.
- 长期接受MTX治疗的类风湿性关节炎患者有风险.
研究的目的:
- 报告一种MTX诱导的三叶缺陷骨折的病例.
- 突出早期诊断和MTX骨质病治疗调整的重要性.
- 强调骨折愈合和预防进一步的骨折.
主要方法:
- 一个72岁的女性类风湿性关节炎患者的病例报告,接受了超过10年的MTX治疗.
- 在没有先前的创伤的情况下诊断出三叶骨缺陷骨折.
- 停止MTX治疗并开始骨质合成药治疗.
主要成果:
- 患者经历了明显的临床改善,并在停止MTX和骨代谢治疗后迅速愈合骨折.
- 磁共振成像 (MRI) 促进了早期诊断.
- 治疗调整导致了成功的结果.
结论:
- MTX骨质病症可能导致缺陷骨折.
- 早期的MRI诊断对于怀疑MTX骨质病至关重要.
- 及时调整治疗,包括停止MTX和骨动态疗法,可以改善愈合并降低风险.
相关概念视频
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
488
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
488
01:29Therapeutic Drug Monitoring: Affecting Factors
200
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
200