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Can Kong¹, Dingsheng Kong², Junjie Hu¹

¹Department of Gastrointestinal Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Frontiers in veterinary science

|October 6, 2025

概括

在腹部外科手术后的小鼠模型中,全括管营养 (TPN) 损害了肠道屏障功能,超过了肠道营养 (EN). 这项研究建立了一个可靠的模型来调查TPN诱导的肠损伤.

科学领域:

胃肠病学胃肠病学
手术营养是指手术营养.
动物模型动物模型

背景情况:

腹部手术需要营养支持.
全方位腹腔营养 (TPN) 可以导致肠道屏障受损.
建立一个可靠的动物模型对于研究TPN效应至关重要.

研究的目的:

创建一个小鼠模型,比较腹部手术后的肠道营养 (EN) 和TPN.
评估EN与TPN对肠道屏障完整性的影响.
为研究TPN诱导的肠壁功能障碍提供一个模型.

主要方法:

小鼠接受了腹部手术 (尾切除术),并随机分配到EN或TPN组.
营养支持是通过十二指肠或中央静脉导管进行的.
评估的生存率,小的高度,细胞增殖,杯状/Paneth细胞和紧密结合蛋白 (ZO-1,occludin).

主要成果:

在EN和TPN组之间生存率没有显著差异.
与EN组相比,TPN组显著减少了小肠小的高度,上皮细胞的增殖,杯状细胞,帕内斯细胞和ZO-1/occludin表达.
这些发现表明TPN对肠道屏障标记有负面影响.

结论:

开发的小鼠模型有效地证明了在不同的营养支持下肠道屏障功能障碍.
这种模型适合进一步研究TPN引起的肠壁损伤的病原性.
这项研究强调了TPN在手术后对肠道健康的有害影响.

关键词:

ZO-1 是一个ZO-1 肠道营养肠道营养肠道营养肠道屏障肠道屏障肠道屏障鼠标模型鼠标模型鼠标模型总体亲肠道营养

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