登革热患者自发静脉血栓形成:发表病例报告的系统分析
Tanmoy Ghatak1, Nidhi Singh2, Rupali Awale Bhalchandra3
1Department of Emergency Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Journal of global infectious diseases
|October 6, 2025
概括
登革热患者的自发静脉血栓形成 (SVT) 是罕见的,但可以控制的. 抗凝固疗法显示有效,所有患者在没有重大出血并发症的情况下存活下来.
科学领域:
- 内部医学 内部医学
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 自发静脉血栓塞 (SVT) 是患有登革热 (DF) 的患者罕见的并发症.
- 在DF中,血栓事件和出血倾向的同时存在,通常是由于血栓细胞减小,这带来了重大管理挑战.
- 了解DF中SVT的特征和结果对于临床决策至关重要.
研究的目的:
- 系统地审查有关登革热患者自发静脉血栓形成的英语文献.
- 分析病因学,临床表现,管理策略和与DF中SVT相关的患者结果.
- 为了确定这种复杂的疾病的有效治疗方法.
主要方法:
- 在主要数据库 (PubMed,CINAHL,Cochrane Library,Clinical Key,Google Scholar) 进行了全面的文献搜索,截至2024年10月31日.
- 包括报告DF患者SVT的研究,数据提取侧重于人口统计,诊断,治疗,并发症和结果.
- 审查遵循了科克伦协作指南和PRISMA 2020声明.
主要成果:
- 涉及19名患者的15项研究符合本系统性审查的纳入标准.
- 患者的平均年龄为43.26岁,SVT通常发生在发烧后6天.
- 大多数患者 (57.8%) 患有血小板缺血,57.8% 接受低分子量肝素治疗;所有患者都没有严重出血而生存.
结论:
- 登革热中SVT强调了血栓和出血状态并存的可能性.
- 标准化管理方法,包括抗凝药,在处理这些复杂的病例中似乎是有效的.
- 进一步的研究可能会在患有SVT的DF患者中阐明最佳的抗凝策略.
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