维生素D通过IL-27/P38MAPK/PGC-1α通路促进白色脂肪变色
Yanqiu Zhou1,2, Junfang Shu1, Yueying Zhao1
1Department of Nutrition and Food Hygiene, School of Public Health, Southwest Medical University, Luzhou, China.
Frontiers in nutrition
|October 6, 2025
概括
维生素D3 (VD3) 可能通过影响IL-27/P38MAPK/PGC-1α通路来促进白色脂肪细胞的色. 这项研究探讨了VD3
科学领域:
- 代谢过程中的代谢.
- 内分泌学 在内分泌学.
- 细胞生物学 细胞生物学
背景情况:
- 肥胖是一个重大的公共卫生挑战.
- 维生素D3 (VD3) 越来越多地被认为对肥胖的潜在作用.
- 了解将VD3与肥胖联系起来的分子机制至关重要.
研究的目的:
- 为了研究VD3对IN-27 (IL-27) 水平的影响.
- 阐明VD3影响白色脂肪组织色的分子途径.
- 检查IL-27/P38MAPK/PGC-1α通路在VD3中介作用中的作用.
主要方法:
- 在肥胖与健康个体中对血清25(OH) D3和IL-27进行比较分析.
- 使用Wistar大鼠 (CON,HFD,HFD+VD3) 进行生物化学,mRNA和蛋白质表达分析的体内研究.
- 使用3T3-L1细胞进行体外研究,包括高缩脂肪模型,基因淘汰 (IL-27,PGC-1α) 和酸醇治疗.
主要成果:
- 观察到血清25(OH) D3和IL-27之间的相关性.
- 在HFD大鼠和3T3-L1细胞中,VD3干预减少了脂质积累和炎症标志物 (IL-6,MCP-1).
- VD3显著上调VDR,IL-27R,P38MAPK,PGC-1α,UCP-1和CD137的表达,其中IL-27和PGC-1α调节了这些效应.
结论:
- 维生素D3促进了白色脂肪组织的色.
- IL-27/P38MAPK/PGC-1α信号通路是VD3对脂肪细胞色的影响的关键调解者.
- 这些发现表明VD3在控制肥胖方面具有潜在的治疗作用.
相关概念视频
Role of Skin in Vitamin D Synthesis
7.5K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
7.5K
TGF - β Signaling Pathway
10.5K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.5K
Cholesterol: Significance and Regulation
1.2K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
1.2K
PI3K/mTOR/AKT Signaling Pathway
5.3K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
5.3K
Regulation of Metabolism
11.4K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
11.4K


