营养对HPV相关炎症的影响:系统性审查和元分析
1Department of Gynaecology and Obstetrics, The First People's Hospital of Shangqiu, Shangqiu, Henan, China.
Frontiers in nutrition
|October 6, 2025
概括
适当的微量营养素摄入量,包括维生素A,D,E,B12,叶酸和等矿物质,可以减少人类乳头瘤病毒 (HPV) 的持续性,降低宫内皮质瘤 (CIN) 和宫癌的风险.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 病毒学 病毒学
背景情况:
- 人类乳头瘤病毒 (HPV) 慢性感染是宫内皮质瘤 (CIN) 和宫癌的主要原因.
- 微量营养素缺乏可能在HPV的持续性和宫癌的发展中发挥作用.
研究的目的:
- 系统地审查和元分析微量营养素摄入量/状态与HPV持久性,CIN和子宫癌风险之间的关联.
- 评估特定营养干预措施在管理与HPV相关的宫疾病中的有效性.
主要方法:
- 在PubMed,EMBASE,Cochrane图书馆和谷歌学者中进行了全面的文献搜索,截至2025年4月.
- 包括来自17个国家的77项研究,包括病例控制,横截面,RCT,队列和嵌套研究.
- 使用随机效应模型计算了聚合估计,GRADE评估了对结果的信心.
主要成果:
- 较高的饮食摄入量或微量营养素血清水平与减少HPV持续性和较低的CIN和宫癌风险有关.
- 维生素E,维生素D,维生素A,叶酸和维生素B12对HPV和子宫瘤产生显著的保护作用.
- ,和在增强免疫力,减少氧化应激和抑制病毒方面显示出潜在的益处,有助于CIN回归.
结论:
- 通过饮食或补充剂优化微量营养素状况可能是预防和管理与HPV相关的宫癌的可行策略.
- 对特定营养干预及其作用机制的进一步研究是有必要的,以支持临床实践.
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