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Updated: Jan 16, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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CHAF1B:在肝细胞癌中,索拉费尼布耐药性背后的隐藏罪祸首

Wenfeng Zhuo1, Jiali Zhao1, Zhouying Zheng1

  • 1Department of Hepatobiliary Surgery, the Fifth Affiliated Hospital, Sun Yat-sen University 519000 Zhuhai, Guangdong, China.

International journal of medical sciences
|October 6, 2025
PubMed
概括

染色体组合因子1B (CHAF1B) 通过激活PI3K/Akt/HIF-1α通路,驱动肝细胞癌 (HCC) 中的索拉芬尼抗性. 用索拉费尼布向CHAF1B为HCC患者提供了一个有前途的治疗策略.

关键词:
在CHAF1B中.在PI3K/Akt/HIF-1α信号通路中.肝细胞癌是肝细胞癌.索拉费尼布耐药性 索拉费尼布耐药性

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