在喘患者中循环miRNAs的下调; 病例对照研究
Christian A Trejo-Jasso1, Héctor Isaac Rocha-González1, Eduardo Montes-Martínez2
1Escuela Superior de Medicina, Departamento de Posgrado, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
International journal of medical sciences
|October 6, 2025
概括
这项研究发现,与健康个体相比,喘患者的特定循环microRNAs (miRNAs) 水平较低. 这些miRNA显示出作为预测喘的非侵入性生物标志物的潜力.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 肺部病理学 肺部病理学
背景情况:
- 微RNAs (miRNAs) 是炎症性疾病的关键非侵入性生物标志物.
- 了解miRNA表达特征可以预测喘等疾病中的疾病活性.
研究的目的:
- 研究喘患者与健康对照组 (HC) 的不同miRNA表达特征.
- 为了确定潜在的循环miRNA生物标志物用于喘预测.
主要方法:
- 从喘患者和HC患者的血中评估了84个miRNA,使用实时PCR.
- 在独立队列中验证了观察到的miRNA表达变化.
- 评估了miRNA水平,BMI和FEV1.1之间的相关性.
主要成果:
- 与HC相比,喘患者的miR-17-5p,miR-106b-5p和miR-126-3p水平显著降低.
- 喘患者的miR-223-3p水平也较低,尽管没有统计学意义 (p=0.13).
- 研究的miRNAs与BMI或FEV1.1之间没有发现显著的相关性.
结论:
- 循环中的miRNAs,包括miR-17-5p,miR-106b-5p和miR-126-3p,可以作为预测喘的有价值生物标志物.
- 需要进一步的研究来探索这些miRNAs在喘中的诊断和预后效用.
关键词:
喘 喘 是一种生物标志物 生物标志物在 miR-106b-3p 中使用.在 miR-126-3p 中使用.在 miR-17-5p 中.在 miR-223-3p 中使用.微核糖核酸是微核糖核酸中的一种.更多相关视频
08:14MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
Published on: October 26, 2017
16.1K
05:31Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
10.8K
相关概念视频
01:20Asthma: Pathogenesis and Management
1.2K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.2K
01:22MicroRNAs
3.7K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.7K
01:22MicroRNAs
23.8K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.8K