基于Rbr切除状态的食道癌患者的复发模式和预后
Peng Zhang1,2, Guoqing Zhang1,3, Kaishang Zhang1,2,3
1Department of Thoracic Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Frontiers in oncology
|October 6, 2025
概括
对食道状细胞癌 (ESCC) 的新Rbr分类表明,Rbr阳性患者具有更高的局部区域复发 (LRR) 风险和更差的无LRR生存率 (LRRFS). 这一发现凸显了对ESCC复发模式的进一步调查的必要性.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 癌症研究 癌症研究
背景情况:
- 完全切除 (R0) 和病理完全响应 (pCR) 并不能排除食道状细胞癌 (ESCC) 的复发.
- 现有的分类可能无法完全捕捉治疗后复发风险.
- 提出一种新的切除状态,Rbr+/-,以补充R0分类.
研究的目的:
- 在ESCC患者中引入和评估Rbr+/-分类.
- 评估Rbr状态与局部区域复发 (LRR),无LRR生存率 (LRRFS) 和整体生存率 (OS) 之间的关联.
主要方法:
- 对443名接受新辅助治疗和手术治疗的ESCC患者的回顾性审查.
- 应用重叠权重 (OW) 来平衡Rbr+和Rbr-组之间的基线特征.
- 后勤和考克斯回归分析,以确定Rbr状态对复发和生存结果的影响.
主要成果:
- 在OW后,Rbr+组 (141名患者) 的LRR率明显高于Rbr-组 (302名患者) 的LRR率 (20.1%对11.4%,p=0.034).
- R+状态独立地与LRR风险增加 (OR:2.19,p=0.018) 和较差的LRRFS (HR:2.15,p=0.016) 相关.
- 在Rbr+状态和整体生存期 (OS) (HR:1.52,p=0.120) 之间没有发现显著的关联.
结论:
- Rbr+分类识别了ESCC患者具有更高的局部区域复发风险和减少无LRR存活率.
- 在这个队列中,Rbr状态似乎没有显著影响整体存活率.
- 需要进行前性研究来验证这些发现,并完善ESCC的预后评估.
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