尼泊尔慢性阻塞性肺病患者的认知障碍:一个横截面研究
Pashupati Pokharel1,2, Surakshya Khanal3, Ranjeet Ghimire1
1Maharajgunj Medical Campus, Institute of Medicine Tribhuvan University Kathmandu Nepal.
Health science reports
|October 6, 2025
概括
在尼泊尔,近90%的慢性阻塞性肺病 (COPD) 患者经历认知衰退. 年龄,恶化频率和PaCO2水平是关键预测指标,突出显示需要进行例行查和综合康复策略.
科学领域:
- 肺部医学 肺部医学
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 慢性阻塞性肺病 (COPD) 与认知障碍有关,影响生活质量.
- 在尼泊尔的COPD患者中,认知障碍的患病率和决定因素尚未得到充分研究.
研究的目的:
- 为了确定尼泊尔COPD患者认知障碍的患病率.
- 在这个人群中识别与认知障碍相关的因素.
主要方法:
- 在尼泊尔的一家三级医院对203名COPD患者进行了横截面研究.
- 数据收集包括社会人口统计学,临床和生物化学参数.
- 使用尼泊尔语翻译的罗兰德普世痴呆症评估尺度评估认知功能;用于分析的逻辑回归.
主要成果:
- 几乎90%的患者表现出认知障碍 (46.3%轻度,42.9%痴呆症).
- 重要预测因素包括年龄较大 (≥65岁),频繁恶化 (>1/年),以及较低的PaCO2水平.
- 保护因素包括COPD持续时间较长 (≥10年) 和因恶化病入院的次数较少.
结论:
- 在尼泊尔的COPD患者中,认知能力下降的高患病率需要引起注意.
- 年龄,恶化频率和PaCO2是重要的预测因素.
- 常规认知查和综合康复对于改善患者的治疗结果至关重要.
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