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Ayema Haque¹, Channing Pezet¹, Aidrian Ranjith¹

¹Internal Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, USA.

|October 6, 2025

概括

摄入高剂量的甲状腺素 (MTX) 可以导致严重的神经毒性,包括脑梗塞. 及时的leucovorin治疗可以逆转精神状态的改变,强调谨慎的MTX剂量和监测.

科学领域:

神经学神经学
毒理学毒理学毒理学
药理学药理学是指药理学的学科.

背景情况:

甲托雷克萨特 (MTX) 与已知影响多个器官系统的毒性有关.
由于有毒性问题,高剂量MTX的摄入很少发生.
神经毒性是MTX的潜在副作用之一.

研究的目的:

报告一种严重的MTX诱导的神经毒性病例.
为了强调准确的MTX处方和管理的重要性.
为了说明在MTX神经毒性中诊断结果和治疗反应.

主要方法:

一个患有大量MTX过量的病人的病例报告.
神经成像 (MRI) 用于识别大脑病变.
神经状态和治疗反应的临床评估.

主要成果:

患者在一周内摄入了七周的MTX.
核磁共振扫描显示了右额叶,额叶和叶 (MCA分水) 的亚急性心脏病发作.
柳科沃林治疗导致改变精神状态的改善.

结论:

大规模的MTX摄入会导致严重的神经毒性,包括脑梗塞.
准确的剂量和患者教育对于预防MTX毒性至关重要.
莱可沃林救援疗法在管理MTX诱导的神经毒性方面是有效的.

关键词:

脑白细胞病变 (leukoencephalopathy) 是一种脑白细胞病变.甲基酸甲基的神经毒性甲基酸盐毒性甲基酸盐毒性有关粘膜炎的疾病牛皮关节炎牛皮关节炎

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