描述一个国家队列的患者与左心室附属物闭塞装置的患者
1Department of Emergency and Hospital Medicine, University of South Florida Morsani College of Medicine, Lehigh Valley Health Network, Bethlehem, USA.
Cureus
|October 6, 2025
概括
左心房尾阻塞 (LAAO) 可能比以前认为的风险更高,特别是在具有高CHA2DS2-VASc分数的患者中. 可能需要进一步的抗凝药来减轻这种增加的风险.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 医疗器械 医疗器械
背景情况:
- 脑卒中是心房动的一个重要并发症.
- 左心房尾闭塞 (LAAO) 装置是预防中风的抗凝治疗的替代方案.
- 了解与LAAO相关的风险对于患者管理至关重要.
研究的目的:
- 描述与左心室尾阻塞 (LAAO) 装置植入相关的中风风险.
- 在接受LAAO的患者中使用CHA2DS2-VASc得分来分析中风风险分层.
- 将当代LAAO队列中的中风风险与历史数据进行比较.
主要方法:
- 利用了Epic Cosmos数据集,包括超过2.96亿个患者记录.
- 在2021年至2023年期间收集了51682名接受LAAO治疗的患者队列.
- 风险分层的患者使用CHA2DS2-VASc得分和LAAO后中风的计算危险比率.
主要成果:
- 该研究队列年龄较大,与以前发表的队列相比,其中风风险更高.
- 较高的CHA2DS2-VASc评分 (7-9) 与明显增加的中风风险有关 (HR 4.88-6.32).
- 接受LAAO治疗的患者的平均年龄明显高于之前的研究 (p < 0.001).
结论:
- 在LAAO植入后,中风风险可能比之前报告的要高.
- 患有高CHA2DS2-VASc评分的患者可能会从LAAO后的额外抗凝治疗中受益.
- 在LAAO安置后,CHA2DS2-VASc得分有效地对患者中风风险进行分层.
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