在喀麦隆西南部的高风险群体中,同期活跃的E型肝炎和B型肝炎病毒感染的发病率低
Macqueen Ngum Mbencho1,2, Eric A Achidi3, Stephen Mbigha Ghogomu2,3
1Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research (DZIF), Tübingen, Germany.
IJID regions
|October 6, 2025
概括
在喀麦隆,暴露于E型肝炎病毒 (HEV) 是常见的,但在艾滋病毒感染者,孕妇和献血者中,与乙型肝炎病毒 (HBV) 的活性共感染是罕见的. 这项研究评估了这些群体中HEV的流行率.
科学领域:
- 肝病学和病毒学.
- 传染病 流行病学 流行病学
背景情况:
- 与乙型肝炎病毒 (HEV) 和乙型肝炎病毒 (HBV) 的同时感染带来临床挑战,特别是在脆弱人群中.
- 了解HEV患病率和活性共感染对于在流行HBV的地区管理肝病至关重要.
研究的目的:
- 在喀麦隆西南部,确定HEV血清流行率并检测先前暴露于HBV的个体中的HEV病毒性病.
- 调查艾滋病毒感染者,孕妇和献血者活跃HBV-HEV共感染的发生情况.
主要方法:
- 分析了三个队列 (艾滋病毒感染者,孕妇,献血者) 的确诊HBV暴露 (抗HBc总阳性).
- 使用ELISA对抗HEVIgG和IgM进行查.
- 通过RT-PCR检测HEVRNA,并在HBsAg阳性个体中定量HBVDNA.
主要成果:
- 艾滋病毒感染者的HEV IgG血清流行率为8.6%,孕妇为5.7%,献血者为12.0%.
- 在两个献血者 (基因型3a) 和两个孕妇 (基因型3e) 中检测到HEVRNA.
- 在任何队列中都没有观察到同时活跃的HBV和HEV复制.
结论:
- 之前的HEV暴露在喀麦隆西南部的研究人口中相对普遍.
- 在该地区,活跃的HBV-HEV共感染在HIV感染者,孕妇和献血者中似乎是罕见的.
- 研究结果强调需要在高风险群体中继续对病毒性肝炎进行监测.
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