在2,996名在单一中心检查不孕症的男性中,男性生育能力参数的种族差异
Ralf Henkel1,2,3, Haitham Elbardisi4,5, Ahmad Majzoub4,5
1LogixX Fertility Section, LogixX Pharma, Theale, Berkshire, UK.
Arab journal of urology
|October 6, 2025
概括
在男性生育指标上存在种族差异,包括精子DNA碎片化和氧化应激. 当前的全球参考值可能不适用于所有人,这表明需要针对特定种族进行andrological诊断.
科学领域:
- 安德罗学与人类学
- 生殖医学 生殖医学
- 人类遗传学 人类遗传学
背景情况:
- 在临床参数的种族差异被注意到在医学领域,包括andrology.
- 目前的雄性病学诊断往往依赖于世界卫生组织标准化的参考值,可能忽视了种族差异.
- 这种差异需要对种族如何影响关键的andrological参数进行调查.
研究的目的:
- 在不育男性中调查激素和精液参数的显著种族差异.
- 为了在不同种族群体中比较精子DNA碎片化 (SDF) 和精子氧化应激 (ORP).
- 评估当前全球参考值在雄性病学中的适用性.
主要方法:
- 对2,996名不育男性的丸体积,精子度,运动能力,形态和活力的分析.
- 确定标准激素,精子DNA碎片化 (SDF) 和氧化降解潜力 (ORP).
- 对这些参数进行了对撒哈拉以南,高加索,中亚/南亚,中东,北非和东南亚男性的比较分析.
主要成果:
- 在多个参数和正常参考值发生率方面观察到显著的种族差异.
- 中亚/南亚男性的精子平均度最高,而东南亚男性的精子平均度最低.
- 与其他群体相比,高加索男性的精子DNA碎片化 (SDF) 和氧化减少潜力 (ORP) 最低.
结论:
- 这项研究突出了在andrological参数和正常值发病率方面存在显著的种族差异.
- 全球标准化的参考值用于andrological诊断可能需要重新评估.
- 建议对更大的队列和功能性精子参数进行进一步研究,承认小高加索样本大小的局限性.
相关概念视频
01:23Infertility in Males
525
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
525
01:41Spermatogenesis
121.8K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
121.8K
01:28Infertility in Females
3.6K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
3.6K
01:20Disorders of the Male Reproductive System
4.0K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
4.0K
02:45The Ratio of X Chromosome to Autosomes
9.4K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
9.4K