在糖尿病和非糖尿病患者的牙炎中产生β-乳酸酶的细菌的患病率和特征:一项比较的微生物学研究
Mohanned Mohamed Alwashsiah1, Asma Abdellatif Abbas1
1Microbiology Department, Faculty of Pharmacy, Misurata University, Misurata, Libya.
Access microbiology
|October 6, 2025
概括
糖尿病增加了牙周炎患者的口腔细菌多样性和格拉姆阴性感染,导致更多的beta-lactamase产生细菌. 这突显了糖尿病是抗生素耐药性口腔感染的危险因素.
科学领域:
- 口腔微生物学 口腔微生物学
- 传染性疾病 传染性疾病
- 内分泌学 在内分泌学.
背景情况:
- 牙炎是一种可逆的牙炎,如果不治疗,可以发展为牙周炎.
- 糖尿病会损害宿主防御,改变口腔微生物群,增加感染易感性.
研究的目的:
- 确定在糖尿病和非糖尿病牙炎患者中产生β-乳糖酶的细菌的患病率和特征.
- 为了比较患有牙炎的糖尿病人和非糖尿病人之间的口腔微生物概况.
主要方法:
- 从37名牙周炎患者 (17名糖尿病患者,20名非糖尿病患者) 的牙拭片中培养和鉴定出细菌分离物.
- 使用 आयो多米色度测试评估β-乳酸酶活性.
- 根据临床和实验室标准研究所指导方针确定抗菌素敏感性.
主要成果:
- 多微生物感染在糖尿病患者 (82.4%) 中比非糖尿病患者 (45.0%) 更常见.
- 糖尿病患者显示,像Pseudomonas aeruginosa和Enterobacteriaceae这样的阴性细菌的患病率更高.
- 67.7%的分离物产生了β-乳糖酶,对安培和氨基氨酸具有很高的耐药性.
结论:
- 糖尿病与增加的微生物多样性,格拉姆阴性殖民化和牙炎中的β-乳糖酶产生细菌有关.
- 研究发现,糖尿病是抗生素耐药性口腔感染的危险因素.
- 强调需要对高风险人群进行抗菌药物管理和耐药性监测.
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