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iComBat:在DNA甲基化阵列数据中进行批量效应校正的增量框架

Yui Tomo1, Ryo Nakaki2

  • 1National Institute of Infectious Diseases, Japan Institute for Health Security, 1-23-1 Toyama, Shinjuku-Ku, 162-0052, Tokyo, Japan.

Computational and structural biotechnology journal
|October 6, 2025
PubMed
概括

这项研究引入了一个增量框架来纠正DNA甲基化数据中的批量效应. 这种方法有效地更新了新数据的分析,而不会影响以前处理的样本,这对于纵向衰老研究至关重要.

关键词:
这就是为什么Combat ComBat.经验贝叶斯估计的估计.表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.一个微阵列的微阵列.重复测量的重复测量

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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