早期生活逆境和青少年底侧桃体活动对皮质边缘连接和行为的互动影响
Caitlyn R Cody1, Emilce Artur de la Villarmois2, Anabel M M Miguelez Fernández2
1Department of Psychology, Northeastern University, Boston, MA, 02115, USA.
Neurobiology of stress
|October 6, 2025
概括
生命早期的逆境 (ELA) 导致底侧杏仁体 (BLA) 和前额叶皮层 (PFC) 之间持久的超连接. 在青春期减少BLA活性会影响这种发展,这表明抑制信号发挥了作用.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 行为生物学 行为生物学
背景情况:
- 早期生活逆境 (ELA) 影响皮质膜发育,并与焦虑有关.
- 在青春期,ELA诱导基侧杏仁体 (BLA) 到前额叶皮层 (PFC) 投射的超内核化.
- 由ELA引起的皮质膜变化背后的发育机制尚不清楚.
研究的目的:
- 研究如何培养环境和神经元活动相互作用以影响行为和皮质膜连接.
- 为了确定青春期减少BLA活性是否会影响行为和PFC内化.
- 阐明抑制信号在ELA诱导的BLA-PFC超连接性中的作用.
主要方法:
- 为了 ELA,使用了一种母体分离 (MS) 的大鼠模型.
- 测量了由BLA引起的PFC局部场势和探索性行为.
- 在青春期服用急性BLA抑制和成年期量化BLA-PFC轴突发炎.
主要成果:
- 暴露于MS的青少年表现出高度的探索行为和增强的BLA-PFC连接.
- 青少年BLA抑制使MS动物的探索行为正常化.
- 在对照动物中抑制BLA活性增加了BLA-PFC内化,表明发育性可塑性.
结论:
- 在成年后,ELA会导致持久的BLA-PFC超内尔化.
- 青少年的BLA活动会影响皮质膜投射的发展.
- BLA-PFC投影的异常发展可能涉及到BLA内部的抑制信号的改变.
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