阿斯伯吉勒斯内心炎:一种罕见但严重的并发症在治疗易布鲁丁尼布期间
Luca Mezzadri1,2, Ilaria Giuseppina Chiara Caramma1, Irene Maria Sciabica3
1Infectious Diseases Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Case reports in infectious diseases
|October 6, 2025
概括
本病例报告详细介绍了一名因慢性淋巴细胞白血病而接受伊布鲁替尼治疗的患者的阿斯伯吉尔菌内心炎. 尽管进行了积极的治疗,但Aspergillus内心炎仍然是一个严重的疾病,死亡率高.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
- 在瘤学瘤学.
背景情况:
- 阿斯伯吉illus内心炎 (AE) 是一种罕见的,危及生命的感染,死亡率高.
- 用于慢性淋巴细胞白血病 (CLL) 的易布鲁替尼与侵入性阿斯伯吉洛症有关,但AE病例未经记录.
- 这项研究呈现了在接受ibrutinib的患者中首次记录的AE病例.
研究的目的:
- 报告一个独特的Aspergillus内心炎病例,该病例发生在治疗IBRUTINIB治疗复发性CLL的患者中.
- 突出AE的诊断和治疗挑战,特别是在有心脏器械的免疫受损患者中.
- 强调早期识别和积极管理AE的关键需求.
主要方法:
- 一个71岁的男性病例研究,患有复发性CLL,正在接受ibrutinib治疗.
- 诊断工作包括计算机断层扫描,心声扫描和真菌标记 (β-D-葡萄糖,银河).
- 治疗涉及经验性伊萨武科纳,随后是紧急的外科干预 (中枢置换,ICD提取).
主要成果:
- 该患者出现了暗示系统性感染的症状,并被发现有一个大型的中枢植被与植入式心脏转换器-除器 (ICD) 涉.
- 血液和门培养证实了阿斯伯吉勒斯烟虫感染.
- 尽管迅速进行了手术和抗真菌治疗,但该患者经历了致命的并发症.
结论:
- 阿斯伯吉illus内心炎是一种严重的疾病,死亡率高,即使结合抗真菌和手术治疗.
- 临床医生应该怀疑AE在免疫受损的患者,那些心脏手术史,或植入心脏设备.
- 早期诊断和积极干预对于改善AE的结果至关重要.
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