微生物代谢物及其对瘤微环境的影响
Huanglin Duan1, Baisheng Xu1, Peiyue Luo2
1Department of Urology, The First People's Hospital of Xiushui, Jiujiang, Jiangxi, China.
Frontiers in immunology
|October 6, 2025
概括
来自肠道微生物群的微生物代谢物显著影响瘤免疫力和免疫疗法的有效性. 了解这些代谢物提供了克服癌症治疗耐药性的新策略.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
背景情况:
- 瘤免疫疗法显示出希望,但由于免疫抑制环境和耐药性,在固体瘤中面临挑战.
- 免疫细胞的代谢重编程对于理解瘤免疫逃避和治疗耐药性至关重要.
- 人类开始的微生物组作为"第二个基因组"显著影响宿主生物学.
研究的目的:
- 审查微生物代谢物在调节瘤免疫和免疫治疗中的调节作用.
- 检查通过微生物代谢物影响免疫细胞代谢和瘤微环境的代谢机制.
- 突出微生物群代谢基于干预精密瘤学的潜力.
主要方法:
- 关于微生物代谢物和瘤免疫代谢的研究的综合文献综述.
- 分析SCFA,胆汁酸,类代谢物和LPS等代谢物如何影响免疫细胞的机制.
- 检查这些代谢物如何重编程免疫细胞代谢途径.
主要成果:
- 微生物代谢产物作为关键信息传递者,将肠道微生物群与瘤免疫代谢联系起来.
- 特定代谢物 (SCFA,胆汁酸,托代谢物,LPS) 调节瘤免疫和免疫治疗反应.
- 这些代谢物塑造瘤的免疫微环境,并通过重新编程免疫细胞代谢来影响治疗疗效.
结论:
- 微生物代谢产物在瘤免疫代谢中发挥着核心的调节作用,类似于'第二个基因组'.
- 了解这些相互作用为阐明免疫疗法耐药性的机制提供了基础.
- 准微生物群代谢为开发新型精确癌症干预措施提供了潜在的途径.
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