在临床试验中进行前性临床试验招生改进混合研究的理由和协议
Patrick Lewicki1, Sabrina Clark1, Elaina Shoemaker1
1Department of Urology, University of Michigan, Ann Arbor, MI, USA.
Contemporary clinical trials communications
|October 6, 2025
概括
电子邮件广告活动可以提高临床试验招生率. 这项研究使用了一项试验内研究 (SWAT) 来评估未来入学干预措施的有效性和改进方法.
科学领域:
- 临床研究方法论临床研究方法论
- 医疗服务研究 医疗服务研究
- 翻译科学是翻译的科学.
背景情况:
- 临床试验招生是一个重大挑战,基于证据的改善策略有限.
- 面向供应商的干预措施,如广告活动,显示出潜力,但需要严格的评估.
- 在临床试验中缺乏对此类干预措施的前性评估.
研究的目的:
- 评估面向供应商的电子邮件广告活动对临床试验招生的有效性.
- 评估实施结果,包括电子邮件参与度量 (打开,点击).
- 完善试验内研究 (SWAT) 方法,用于评估未来的试验改进干预措施.
主要方法:
- 一个随机临床试验被设计成一个试验内的混合实施-有效性研究 (SWAT).
- 该干预涉及一个为期一个月的电子邮件广告活动,针对潜在的注册者.
- 有效性是通过注册人数来衡量,通过电子邮件打开和点击率来实现.
主要成果:
- 初步数据表明,电子邮件广告活动在增强临床试验招聘方面的潜在有效性.
- 这项研究为未来对招生改善干预措施的研究建立了基础设施.
- 该协议作为评估类似增强招生策略的模型.
结论:
- 电子邮件广告活动是改善临床试验招生率的可行策略.
- 临床试验研究 (SWAT) 框架对于评估旨在加强临床试验参与的干预措施是有效的.
- 这项研究为未来的研究和临床试验招聘的方法进步提供了基础.
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