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Updated: Jan 15, 2026

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells
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对于in vitro疾病建模的PD患者特异性中脑器官数据的可复制性

Elisa Zuccoli1, Haya Al Sawaf1, Mona Tuzza1

  • 1Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 6, Avenue du Swing, 4367 Belvaux, Luxembourg.

iScience
|October 6, 2025
PubMed
概括

中脑有机体为帕金森病 (PD) 研究提供了可重复的模型. 这项研究证实,与GBA-N370S突变相关的PD表型在不同的有机体批次中一致观察到,验证了它们在疾病建模中的使用.

关键词:
神经科学是一个神经科学.细胞生物学 细胞生物学分子生物学分子生物学俄米克斯 (Omics) 是一个电子产品.

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EPS and iPS Cells in Disease Research01:21

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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