在患有自闭症谱系障碍和发育协调障碍并发的儿童中,白质变化随着康复
Melika Kangarani-Farahani1,2, Jill G Zwicker2,3,4
1Graduate Programs in Rehabilitation Sciences, University of British Columbia, Vancouver, Canada.
Neuroimage. Reports
|October 6, 2025
概括
对日常职业表现的认知导向 (CO-OP) 干预改善了自闭症谱系障碍 (ASD) 和发育协调障碍 (DCD) 的儿童的白质微观结构. 这些大脑变化在干预后的三个月内得到维持.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 儿科康复儿童康复中心
背景情况:
- 高达88%的患有自闭症谱系障碍 (ASD) 的儿童也患有发育协调障碍 (DCD),影响运动技能.
- 对日常职业表现的认知导向 (CO-OP) 是一种有效的干预措施,用于ASD和DCD同时发生的儿童的运动学习.
- 在这个人群中,CO-OP干预对大脑变化的影响尚不清楚.
研究的目的:
- 为了研究CO-OP干预后ASD + DCD儿童白质微观结构的变化.
- 为了确定这些大脑变化是否在干预后三个月内持续存在.
- 探索白质变化与运动功能的改善之间的相关性.
主要方法:
- 一项涉及24名患有ASD+DCD的儿童 (8-12岁) 的准实验性研究.
- 参与者被分配到治疗或等待名单组.
- 扩散张力成像 (DTI) 用于分析CO-OP干预前后白质变化,并在三个月后进行后续扫描.
主要成果:
- 在CO-OP后的小脑白质 (红叶VI和中小脑脚) 中观察到微分异构 (FA) 的显著增加.
- 这些白质改善在三个月的随访中持续存在.
- 通过回归分析,白质变化和运动结果改善之间没有发现显著的关系.
结论:
- 在患有ASD + DCD的儿童中,CO-OP干预证明了改善小脑白质路径的有效性.
- 这些发现支持CO-OP作为这个临床组的有价值的治疗方法.
- 进一步的研究可能会探索这些神经可塑性变化的功能影响.
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